One of the most important challenges in the study of aging is to discover compounds with longevity-promoting activities and to unravel their underlying mechanisms. Royal jelly has been reported to possess diverse beneficial properties.
Exactly how Royal Jelly exerts these effects and which of their components are responsible for these effects are largely unknown.
The purpose of the present study was to determine whether Royal Jelly and its related substances exert a lifespan-extending function in roundworms and to gain insights into the active agents in Royal Jelly and their mechanism of action.
The scientists found that Royal Jelly did indeed extend the lifespan of roundworms and it did this by reducing insulin/IGF-1 signaling. This pathway inﬂuences longevity, reproduction, and diapause in many organisms.
The scientists concluded that these results demonstrate that Royal Jelly and its related substances extend lifespan in roundworms and more importantly, suggest that Royal Jelly may contain longevity-promoting factors.
The complete study can be found in PLoS ONE 6(8): Published: August 9, 2011.
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