The combination of honey and bee pollen (HBM) has claimed to be effective for the treatment of asthma, bronchitis, cancers, peptic ulcers, colitis, various types of infections including hepatitis B, and rheumatism by the herb dealers.
In the present study, in vivo antinociceptive(reducing sensitivity to painful stimuli), anti-inflammatory, gastro protective and antioxidant effects of pure honey and HBM formulation were evaluated comparatively. HBM did not show any significant gastroprotective activity in a single administration at 250 mg/kg dose, whereas a weak activity was observed after three days of successive administration at 500 mg/kg dose.
On the other hand, HBM displayed significant antinociceptive and anti-inflammatory activities at 500 mg/kg dose orally without inducing any apparent acute toxicity or gastric damage.
HBM was also shown to possess potent antilipidperoxidant activity at 500 mg/kg dose against acetaminophen-induced liver necrosis model in mice.
is the process in which free radicals "steal" electrons from the lipids in cell membranes, resulting in cell damage. This process proceeds by a free radical chain reaction mechanism.
On the other hand, pure honey did not exert any remarkable antinociceptive, anti-inflammatory and gastroprotective activity, but a potent antilipidperoxidant activity was determined.
Results have clearly proved that mixing pure honey with bee pollen significantly increased the healing potential of honey and provided additional support for its traditional use.
Total phenolic and flavonoid contents of HBM were found to be 145 and 59.3 mg/100 g of honey, which were estimated as gallic acid and quercetin equivalents, respectively.
The full study can be found in the journal of Pharmaceutical Biology, Volume 48, Number 3, March 2010 , pp. 253-259(7).